Please use this identifier to cite or link to this item:
https://hdl.handle.net/10321/983
DC Field | Value | Language |
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dc.contributor.author | Sabela, Myalowenkosi Innocent | en_US |
dc.contributor.author | Singh, Parvesh | en_US |
dc.contributor.author | Gumede, Njabulo Joyfull | en_US |
dc.contributor.author | Bisetty, Krishna | en_US |
dc.contributor.author | Sagrado, Sagrado | en_US |
dc.date.accessioned | 2014-05-15T09:03:23Z | - |
dc.date.available | 2014-05-15T09:03:23Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Sabela, M.I., Singh, P., Gumede, N.J., Bisetty, K. and Sagrado, S. 2012. Evaluation of Enantioresolution of (±)-Catechin using Electrokinetic Chromatography and Molecular Docking." Journal of Scientific Research in Pharmacy. 1(2): 1-4. | en_US |
dc.identifier.issn | 2277-9469 | - |
dc.identifier.uri | http://hdl.handle.net/10321/983 | - |
dc.description.abstract | This study involves the enantioresolution of (±) catechin with the highly sulphated beta cyclodextrin (HS-β-CD) as a chiral selector using capillary electrophoresis (CE). The purpose of this study was to be tter understand enantioresolution amongst host-guest interactions. Furthermore, molecular docking was carried out to elucidate the mechanism of the enantioselective separations of (±) catechin enantiomers obtained in Electrokinetic chroma tography (EKC). A large difference in the interaction energies observed between the two enantiomers represents significant enantiodifferentiation. Our results also suggest that the host-guest interactions between the phenyl ring of the ligand and the open cavity of the HS-β-CD are due mainly to hydrophobic interactions. Interestingly, the stronger interactions observed with (+)-catechin is consistent with the elution order observed in the CE experiments. | en_US |
dc.format.extent | 4 p | en_US |
dc.language.iso | en | en_US |
dc.publisher | SRP | en_US |
dc.relation.ispartof | Journal of scientific research in pharmacy | en_US |
dc.subject | Enantioresolution | en_US |
dc.subject | Electrokinetic chromatography (EKC) | en_US |
dc.subject | Molecular docking | en_US |
dc.subject.lcsh | Catechin | en_US |
dc.title | Evaluation of enantioresolution of (±)-catechin using electrokinetic chromatography and molecular docking | en_US |
dc.type | Article | en_US |
dc.dut-rims.pubnum | DUT-001768 | en_US |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
Appears in Collections: | Research Publications (Applied Sciences) |
Files in This Item:
File | Description | Size | Format | |
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bisetty_et_al_non_acc_2012_output.pdf | 1.07 MB | Adobe PDF | View/Open |
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