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|Title:||The dysregulation of adipokines in the synergy of diabetes and HIV infection||Authors:||Sydney, Clive
|Keywords:||Adipokines;Diabetes mellitus;Human immunodeficiency virus||Issue Date:||2022||Source:||Haffejee, F.; Sydney, C.; Moodley, M. and Adam, J. 2022. The dysregulation of adipokines in the synergy of diabetes and HIV infection. The Journal of Medical Laboratory Science & Technology. 4(2).||Journal:||The Journal of Medical Laboratory Science & Technology; Vol. 4, Issue 2||Abstract:||
Background: Dysregulated production or secretion of adipokines from adipose tissue may contribute to the pathogenesis of
obesity-linked complications such as diabetes mellitus. Although adipokines have anti-inflammatory activity it is also capable of
causing inflammation. Human immunodeficiency virus (HIV) infection predisposes an individual to the development of diabetes.
Notwithstanding the side effects of antiretroviral therapy (ART), these may also exacerbate adipokine release and thereby promoting
Aim: This study reviews adipokines in the synergy of diabetes comorbid with HIV infection. It also examines the ameliorative action
of ART on adipokines in diabetes.
Method: Multiple databases were used to search for each of the adipokines listed in the study. The role and expression of these
adipokines were highlighted in its relationship to diabetes mellitus and HIV. Relevant articles were identified, selected and used to
write this review article.
Results: This narrative review compares adipokine levels among HIV-infected and uninfected patients who are diabetic and have
insulin resistance (IR). It also addresses the side effect of ART and its contribution to diabetes mellitus in HIV-infected patients.
Adipokines are dysregulated in diabetes and insulin resistance, as well as in patients receiving ART.
Conclusion: Antiretroviral therapy, particularly protease inhibitors and non-nucleoside reverse transcriptase inhibitors, promotes IR
and metabolic abnormalities. Nonetheless, obesity, physical inactivity, immune dysregulation and inflammation are also contributing
factors to IR and diabetes mellitus in HIV-infected patients. Finally, circulating levels of adipokines are dysregulated in diabetes mellitus
and further investigations are necessary
|Appears in Collections:||Research Publications (Health Sciences)|
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checked on Mar 20, 2023
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