Please use this identifier to cite or link to this item: http://hdl.handle.net/10321/3017
Title: Sulfonic acid functionalized boron nitride nano materials as a microwave-assisted efficient and highly biologically active one-pot synthesis of piperazinyl-quinolinyl fused Benzo[c]acridine derivatives
Authors: Murugesan, Arul 
Gengan, Robert Moonsamy 
Anand, Krishnan 
Keywords: Boron nitride;Solid acid catalyst;Knoevenagel reactions;Microwave irradiation;Raman spectroscopy
Issue Date: 2017
Publisher: Elsevier
Source: Murugesan, A. et al. 2017. Sulfonic acid functionalized boron nitride nano materials as a microwave-assisted efficient and highly biologically active one-pot synthesis of piperazinyl-quinolinyl fused Benzo[c]acridine derivatives. Materials Chemistry and Physics. 188: 154-167.
Abstract: Boron nitride nano material based solid acid catalyst was found to be an efficient and reusable sulfonic acid catalyst for the synthesis of one-pot Knoevenagel and Michael type reactions in 3, 3-dimethyl-9-(2-(4-methylpiperazin-1-yl) quinolin-3-yl)-3, 4, 9, 10-tetrahydroacridin-1(2H)-one derivatives under mi-crowave irradiation conditions. The catalyst was prepared by mixing boron nitrile and (3-mercaptopropyl) trimethoxysilane. This is simple and safe method for the preparation of solid acid catalysts. The morphological properties of catalyst determined by using FT-IR, XRD, TEM, SEM and Raman spectroscopy. The synthesised catalyst was employed in Knoevenagel and Michael type reactions to synthesise novel piperazinyl-quinolinyl based acridine derivatives. Furthermore the newly-synthesised compounds have been used for molecular docking in DNA binding studies. The method developed in this study has the advantages of good yield, simplicity coupled with safety and short reaction time. Most importantly it was found that the solid acid catalyst can be recycled with only 5% loss of activity.
URI: http://hdl.handle.net/10321/3017
ISSN: 0254-0584
Appears in Collections:Research Publications (Applied Sciences)

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