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|Title:||Sulfonic acid functionalized boron nitride nano materials as a microwave-assisted efﬁcient and highly biologically active one-pot synthesis of piperazinyl-quinolinyl fused Benzo[c]acridine derivatives||Authors:||Murugesan, Arul
Gengan, Robert Moonsamy
|Keywords:||Boron nitride;Solid acid catalyst;Knoevenagel reactions;Microwave irradiation;Raman spectroscopy||Issue Date:||2017||Publisher:||Elsevier||Source:||Murugesan, A. et al. 2017. Sulfonic acid functionalized boron nitride nano materials as a microwave-assisted efﬁcient and highly biologically active one-pot synthesis of piperazinyl-quinolinyl fused Benzo[c]acridine derivatives. Materials Chemistry and Physics. 188: 154-167.||Abstract:||Boron nitride nano material based solid acid catalyst was found to be an efﬁcient and reusable sulfonic acid catalyst for the synthesis of one-pot Knoevenagel and Michael type reactions in 3, 3-dimethyl-9-(2-(4-methylpiperazin-1-yl) quinolin-3-yl)-3, 4, 9, 10-tetrahydroacridin-1(2H)-one derivatives under mi-crowave irradiation conditions. The catalyst was prepared by mixing boron nitrile and (3-mercaptopropyl) trimethoxysilane. This is simple and safe method for the preparation of solid acid catalysts. The morphological properties of catalyst determined by using FT-IR, XRD, TEM, SEM and Raman spectroscopy. The synthesised catalyst was employed in Knoevenagel and Michael type reactions to synthesise novel piperazinyl-quinolinyl based acridine derivatives. Furthermore the newly-synthesised compounds have been used for molecular docking in DNA binding studies. The method developed in this study has the advantages of good yield, simplicity coupled with safety and short reaction time. Most importantly it was found that the solid acid catalyst can be recycled with only 5% loss of activity.||URI:||http://hdl.handle.net/10321/3017||ISSN:||0254-0584|
|Appears in Collections:||Research Publications (Applied Sciences)|
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