Please use this identifier to cite or link to this item: https://hdl.handle.net/10321/2884
Title: The co-localization of tissue kallikrein and transforming growth factor - beta 1 in the non-cancerous and cancerous kidney
Authors: Moodley, Rumesha
Issue Date: 2003
Abstract: 
Evidence suggests that the induction of tissue kallikrein, and the subsequently formed kinins, enhances proliferation of tumour cells because of their mitogenic property. Additionally, the kinin peptides are believed to promote the invasion of normal tissue by tumour cells. TGF-l is a potent inhibitor of the growth of renal epithelial cells, and is a classical anti-mitogen, which is central to many of its antiproliferative effects. No studies thus far have been performed, as to whether the proposed anti-mitogenesis ofTGF-1 has a regulatory effect on the cell proliferative action of kinins on renal epithelial and carcinoma cells.
Description: 
Submitted in part fulfilment for the Degree of Master of Technology: Biotechnology, Durban Institute of Technology, Durban, South Africa, 2003.
URI: http://hdl.handle.net/10321/2884
DOI: https://doi.org/10.51415/10321/2884
Appears in Collections:Theses and dissertations (Applied Sciences)

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