Please use this identifier to cite or link to this item: http://hdl.handle.net/10321/2547
Title: Synthesis, polymorphism, and insecticidal activity of Methyl 4-(4-chlorophenyl)-8-iodo-2-methyl-6-oxo-1,6-dihydro-4H-pyrimido[2,1-b]quinazoline-3-Carboxylate against Anopheles arabiensis mosquito.
Authors: Venugopala, Katharigatta Narayanaswamy 
Nayak, Susanta K. 
Gleiser, Raquel M. 
Sanchez-Borzone, M. E.
Garcia, D. A.
Odhav, Bharti 
Keywords: Antimosquito properties;Crystallography;Polymorphism;Pyrimido[2,1-b]quinazoline;Synthesis
Issue Date: Jul-2016
Publisher: Wiley Online Library
Source: Venugopala, K.N. et al. 2016. Synthesis, polymorphism, and insecticidal activity of Methyl 4-(4-chlorophenyl)-8-iodo-2-methyl-6-oxo-1,6-dihydro-4H-pyrimido[2,1-b]quinazoline-3-Carboxylate against Anopheles arabiensis mosquito.Chemical Biology and Drug Design. 88(1): 88-96.
Abstract: Mosquitoes are the major vectors of pathogens and parasites including those causing malaria, the most deadly vector-borne disease. The negative environmental effects of most synthetic compounds combined with widespread development of insecticide resistance encourage an interest in finding and developing alternative products against mosquitoes. In this study, pyrimido[2,1-b]quinazoline derivative DHPM3 has been synthesized by three-step chemical reaction and screened for larvicide, adulticide, and repellent properties against Anopheles arabiensis, one of the dominant vectors of malaria in Africa. The title compound emerged as potential larvicide agent for further research and development, because it exerted 100% mortality, while adulticide activity was considered moderate.
URI: http://hdl.handle.net/10321/2547
ISSN: 1747-0277 (print)
1747-0285 (online)
Appears in Collections:Research Publications (Applied Sciences)

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