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Title: Placental leptin mRNA expression and serum leptin levels in pre-eclampsia associated with HIV infection
Authors: Haffejee, Firoza 
Naicker, Thajasvarie 
Singh, Moganavelli 
Kharsany, Ayesha B.M. 
Adhikari, Miriam 
Singh, Ravesh 
Maharaj, Niren 
Moodley, Jagidesa 
Keywords: Leptin mRNA;HIV;Pre-eclampsia
Issue Date: 3-Oct-2016
Publisher: Taylor and Fancis Online
Source: Haffejee, F. et al. 2016. Placental leptin mRNA expression and serum leptin levels in pre-eclampsia associated with HIV infection. Journal of Obstetrics and Gynaecology : 1-5.
Journal: Journal of obstetrics and gynaecology (Online) 
Leptin, primarily produced by adipocytes, is implicated in the development of pre-eclampsia. This study examines placental leptin production and serum leptin levels in HIV infected and uninfected normoten-sive and pre-eclamptic pregnancies. Placental leptin production was analysed by RT-PCR and serum lep-tin levels by ELISA in normotensive (n ¼ 90) and pre-eclamptic (n ¼ 90) pregnancies which were further stratified by HIV status. Placental leptin production was higher in pre-eclampsia compared to normoten-sive pregnancies irrespective of HIV status (p ¼ .04). Serum leptin was non-significantly raised in HIV uninfected (p ¼ .42) but lower in HIV-infected (p ¼ .03) pre-eclampsia. The latter had lower BMI (p ¼ .007) and triceps skin-fold thickness (p < .001) than the HIV uninfected groups with a significant correlation between serum leptin and triceps skin-fold thickness (p < .001), indicative of less adipose tissue in HIV-infected women with consequently lower serum leptin. Thus, serum leptin levels are not indicative of increased placental production when pre-eclampsia is associated with HIV infection.
ISSN: 0144-3615 (Print)
1364-6893 (Online)
Appears in Collections:Research Publications (Health Sciences)

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