Please use this identifier to cite or link to this item:
Title: Chemoprevention of Azoxymethane-induced Colonic Carcinogenesis in Balb/c mice using a modified Pectin Alginate Probiotic
Authors: Odun-Ayo, Frederick Oluwasheyi 
Naicker, Thajasvarie 
Reddy, Lalini 
Mellem, John Jason 
Keywords: Azoxymethane;Colonic cancer;Modified citrus pectin;Probiotic;Galectin-3;Immunohistochemistry
Issue Date: 2015
Publisher: International Institute of AntiCancer Research
Source: Odun-Ayo, F. et al. 2015. Chemoprevention of Azoxymethane-induced Colonic Carcinogenesis in Balb/c mice using a modified Pectin Alginate Probiotic. Anticancer Research. 35(1): 4765-4776.
Journal: Anticancer research 
Background: Increased intake of probiotic dietary fibre reduces colonic cancer risk. Modified citrus pectin (MCP) requires optimal bioactivity to inhibit galectin-3 (GAL-3) and vascular endothelial growth factor (VEGF). This study evaluated the preventative effect of modified pectin alginate (MCPA) probiotic microbeads on azoxymethane (AOM)-induced colonic carcinogenesis in Balb/c mice. Materials and Methods: Optimization of AOM dose duration: 10-15 mg/kg was administered for 2-4 weeks. The optimal AOM dose was initiated prior to intake of MCPA, alginate probiotic (AP) microbeads and MCP in Balb/c mice for 16 weeks; samples were analyzed for colonic histopathology and immunohistochemistry. Results: AOM at 15 mg/kg for 4 weeks induced optimal GAL-3 and VEGF immunostaining. Furthermore, MCPA treatment reduced GAL-3 expression in the colon of AOM-treated mice compared to MCP. Conclusion: MCPA probiotic microbeads increase bioactivity and chemopreventative effect against pre-cancerous colonic lesions and adenocarcinoma through inhibition of GAL-3 and VEGF in the Balb/c mouse model of colonic carcinogenesis.
ISSN: 0250-7005
Appears in Collections:Research Publications (Health Sciences)

Files in This Item:
File Description SizeFormat
Odun-Ayo_ACR_Vol35_No1_2015.pdf872.73 kBAdobe PDFThumbnail
Show full item record

Page view(s)

checked on Jul 15, 2024


checked on Jul 15, 2024

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.