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|Title:||Trifluoroacetic acid: An efficient catalyst for paal-knorr pyrrole synthesis and its deprotection||Authors:||Venugopala, Katharigatta Narayanaswamy
Prasanna, Renuka T.
|Keywords:||Deprotection;Amine;Trifluoroacetic acid;Paal-Knorr pyrrole synthesis;Protection;Acetonylacetone||Issue Date:||2013||Publisher:||AJC||Source:||Venugopala, K. N.; Prasanna, R. T. and Odhav, B. 2013. Trifluoroacetic acid: An efficient catalyst for paal-knorr pyrrole synthesis and its deprotection. Asian Journal of Chemistry. 25(15) : 8685-8689.||Abstract:||In the present work, we demonstrated a simple and an efficient method for the condensation of substituted aryl/heteroaryl amines with acetonylacetone in the presence of trifluoro acetic acid to afford the corresponding 2,5-dimethyl-1-substitued pyrroles using Paal-Knorr synthesis in excellent yields. Trifluoroacetic acid was used under reflux condition for the deprotection of 2,5-dimethyl-1-substitued pyrroles to their corresponding substituted aryl/heteroaryl amines in moderate yields. 2,5-Dimethyl-1-substitued pyrrole were characterized by NMR and LC-MS. The yield of the compounds was found to be excellent. - See more at: http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=25_16_103#sthash.ZgrkcJg7.dpuf||URI:||http://hdl.handle.net/10321/1306||ISSN:||0970-7077|
|Appears in Collections:||Research Publications (Health Sciences)|
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