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Title: Trifluoroacetic acid: An efficient catalyst for paal-knorr pyrrole synthesis and its deprotection
Authors: Venugopala, Katharigatta Narayanaswamy 
Prasanna, Renuka T. 
Odhav, Bharti 
Keywords: Deprotection;Amine;Trifluoroacetic acid;Paal-Knorr pyrrole synthesis;Protection;Acetonylacetone
Issue Date: 2013
Publisher: AJC
Source: Venugopala, K. N.; Prasanna, R. T. and Odhav, B. 2013. Trifluoroacetic acid: An efficient catalyst for paal-knorr pyrrole synthesis and its deprotection. Asian Journal of Chemistry. 25(15): 8685-8689.
Journal: Asian Journal of Chemistry 
In the present work, we demonstrated a simple and an efficient method for the condensation of substituted aryl/heteroaryl amines with acetonylacetone in the presence of trifluoro acetic acid to afford the corresponding 2,5-dimethyl-1-substitued pyrroles using Paal-Knorr synthesis in excellent yields. Trifluoroacetic acid was used under reflux condition for the deprotection of 2,5-dimethyl-1-substitued pyrroles to their corresponding substituted aryl/heteroaryl amines in moderate yields. 2,5-Dimethyl-1-substitued pyrrole were characterized by NMR and LC-MS. The yield of the compounds was found to be excellent. - See more at:
ISSN: 0970-7077
DOI: 10.14233/ajchem.2013.15185
Appears in Collections:Research Publications (Health Sciences)

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