Please use this identifier to cite or link to this item: http://hdl.handle.net/10321/1306
Title: Trifluoroacetic acid: An efficient catalyst for paal-knorr pyrrole synthesis and its deprotection
Authors: Venugopala, Katharigatta Narayanaswamy 
Prasanna, Renuka T. 
Odhav, Bharti 
Keywords: Deprotection;Amine;Trifluoroacetic acid;Paal-Knorr pyrrole synthesis;Protection;Acetonylacetone
Issue Date: 2013
Publisher: AJC
Source: Venugopala, K. N.; Prasanna, R. T. and Odhav, B. 2013. Trifluoroacetic acid: An efficient catalyst for paal-knorr pyrrole synthesis and its deprotection. Asian Journal of Chemistry. 25(15) : 8685-8689.
Abstract: In the present work, we demonstrated a simple and an efficient method for the condensation of substituted aryl/heteroaryl amines with acetonylacetone in the presence of trifluoro acetic acid to afford the corresponding 2,5-dimethyl-1-substitued pyrroles using Paal-Knorr synthesis in excellent yields. Trifluoroacetic acid was used under reflux condition for the deprotection of 2,5-dimethyl-1-substitued pyrroles to their corresponding substituted aryl/heteroaryl amines in moderate yields. 2,5-Dimethyl-1-substitued pyrrole were characterized by NMR and LC-MS. The yield of the compounds was found to be excellent. - See more at: http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=25_16_103#sthash.ZgrkcJg7.dpuf
URI: http://hdl.handle.net/10321/1306
ISSN: 0970-7077
Appears in Collections:Research Publications (Health Sciences)

Show full item record

Page view(s) 50

295
checked on Jul 15, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.