Please use this identifier to cite or link to this item: https://hdl.handle.net/10321/893
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dc.contributor.authorRaj, Raghuen_US
dc.contributor.authorSingh, Pardeepen_US
dc.contributor.authorSingh, Parveshen_US
dc.contributor.authorGut, Jirien_US
dc.contributor.authorRosenthal, Philip J.en_US
dc.contributor.authorKumar, Vipanen_US
dc.date.accessioned2013-08-29T10:34:44Z-
dc.date.available2013-08-29T10:34:44Z-
dc.date.issued2013-04-
dc.identifier.citationRaja, R., Singh, P., Singh, P., Gutc, J., Rosenthalc, P.J. and Kumar, V. 2013. Azide-alkyne cycloaddition en route to 1H-1,2,3-triazole-tethered 7-chloroquinoline-isatin chimeras: Synthesis and antimalarial evaluation. European Journal of Medicinal Chemistry, 62: 590–596.en_US
dc.identifier.urihttp://hdl.handle.net/10321/893-
dc.description.abstractWe describe the synthesis and antimalarial activities of 1H-1,2,3-triazole tethered 7-chloroquinoline-isatin hybrids. Activity against cultured parasites was dependent on the C-5 substituent of the isatin ring as well as the alkyl chain length between the isatin and 7-chloroquinoline moieties. Compound 8h, with an optimum alkyl chain length (n = 3) and a chloro substituent at the C-5 position of the isatin ring, displayed the best activity among the test compounds, with IC50 value of 1.21 μM against cultured W2-strain Plasmodium falciparum.en_US
dc.format.extent7 pen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subject7-Chloroquinoline-isatin conjugatesen_US
dc.subject1H-1,2,3-triazoleen_US
dc.subjectAntimalarial evaluationen_US
dc.subjectStructure–activity relationshipen_US
dc.subject.lcshMalariaen_US
dc.titleAzide-alkyne cycloaddition en route to 1H-1,2,3-triazole-tethered 7-chloroquinoline-isatin chimeras : synthesis and antimalarial evaluationen_US
dc.typeArticleen_US
dc.publisher.urihttp://www.sciencedirect.com/science/article/pii/S0223523413000603/pdfft?md5=981f7a91cb361319d6a41ded99e81abd&pid=1-s2.0-S0223523413000603-main.pdfen_US
dc.dut-rims.pubnumDUT-002772en_US
dc.identifier.doi10.1016/ j.ejmech.2013.01.032-
item.languageiso639-1en-
item.openairetypeArticle-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
Appears in Collections:Research Publications (Applied Sciences)
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