Please use this identifier to cite or link to this item: https://hdl.handle.net/10321/812
Title: The assessment of two year clinical outcomes after stent implantation for the treatment of coronary artery disease
Authors: Harrypaul, Ashika 
Issue Date: 18-Jan-2013
Abstract: 
The sirolimus-eluting stent (Cypher) was the first approved drug-
eluting stent by the Food and Drug Administration in April 2003. This is a stent
that is based on a bare-metal stent and is coated with a layer of polymer
incorporating sirolimus and releasing it by diffusion. Drug-eluting stents
reduced risk of restenosis and repeat revascularization as compared with
bare-metal stents. Clinical data has raised concerns that drug-eluting stents
are associated with late untoward events.
Objectives: The objective of this study was to test the hypothesis that stenting
is safe and effective treatment for coronary artery disease.
Methods and Results: Sirolimus-eluting stenting was performed in 30 patients
with 34 coronary lesions. Detailed clinical follow-up data was collected by
personal interview or telephone contact at 1, 6, 12 and 24 months. Patients
were followed for 2 years for the occurrence of angina and cardiovascular
events namely death, myocardial infarction, stent thrombosis and target lesion
revascularization. The mean age of the cohort was 62.33±10.99 years; 83
percent were male, 6 percent were diabetic, 53 percent had hypertension. In
spite of the overall patient and lesion complexity there were no incidences of
major adverse cardiac events and all patients remained angina free out to two
years. Dual antiplatelet therapy with aspirin and plavix varied from at least
four weeks to one year. One patient had a bleeding event.
Conclusions: Treatment of lesions with sirolimus-eluting stents is associated
with a sustained clinical benefit two years after device implantation.
Description: 
Submitted in fulfillment of the Master’s Degree in Clinical Technology,
Durban University of Technology, Durban, South Africa, Durban, South Africa, 2012.
URI: http://hdl.handle.net/10321/812
DOI: https://doi.org/10.51415/10321/812
Appears in Collections:Theses and dissertations (Health Sciences)

Files in This Item:
File Description SizeFormat
Harrypaul_2012.pdf1.13 MBAdobe PDFThumbnail
View/Open
Show full item record

Page view(s) 20

1,361
checked on Dec 23, 2024

Download(s) 50

787
checked on Dec 23, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.