Please use this identifier to cite or link to this item:
https://hdl.handle.net/10321/5144
DC Field | Value | Language |
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dc.contributor.author | Mbona, Sizwe Vincent | en_US |
dc.contributor.author | Mwambi, Henry | en_US |
dc.contributor.author | Ramroop, Shaun | en_US |
dc.date.accessioned | 2024-02-15T08:52:55Z | - |
dc.date.available | 2024-02-15T08:52:55Z | - |
dc.date.issued | 2023-09-25 | - |
dc.identifier.citation | Mbona, S.V., Mwambi, H. and Ramroop, S. 2023. The importance of the frailty effect in survival models: for multidrug-resistant tuberculosis data. The Open Public Health Journal. 16(1). doi:10.2174/18749445-v16-230912-2023-76 | en_US |
dc.identifier.issn | 1874-9445 | - |
dc.identifier.issn | 1874-9445 (Online) | - |
dc.identifier.uri | https://hdl.handle.net/10321/5144 | - |
dc.description.abstract | Frailty models have been proposed to analyse survival data, considering unobserved covariates (frailty effects). In a shared frailty model, frailties are common (or shared) amongst groups of individuals and are randomly distributed across groups.</jats:p> <jats:title>Objective:</jats:title> <jats:p>In this paper, the authors compared the semi-parametric model to shared frailty models by studying the time-to-death of patients with multidrug-resistant tuberculosis (MDR-TB).</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>Secondary data from 1 542 multidrug-resistant tuberculosis patients were used in this study. STATA software was used to analyse frailty models via the <jats:italic>streg</jats:italic> command.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>Of 1 542 patients diagnosed with MDR-TB, 245 (15.9%) died during the study period; 77 (5.0%) had treatment failure; 334 (21.7%) defaulted; 213 (13.8%) completed treatment; 651 (42.2%) were cured of MRD-TB; and 22 (1.4%) were transferred out. The results showed that 797 (51.7%) were females, and the majority were aged 18 – 30 and 31 – 40 years (35.5% and 35.7% respectively). Most of the patients (71.3%) were HIV-positive. The results also showed that most patients (95.7%) had no previous MDR-TB episodes, and 792 (51.4%) had no co-morbidities. The estimate of the variance for the frailty term in the Weibull gamma shared frailty model was 2.83, which is relatively large and therefore suggests the existence of heterogeneity.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion:</jats:title> <jats:p>The Laplace transform of the frailty distribution plays a central role in relating the hazards, conditional on the frailty, to the hazards and survival functions observed in a population.</jats:p> </jats:sec> | en_US |
dc.format.extent | 8 p | en_US |
dc.language.iso | en | en_US |
dc.publisher | Bentham Science Publishers Ltd. | en_US |
dc.relation.ispartof | The Open Public Health Journal; Vol. 16, Issue 1 | en_US |
dc.subject | Frailty | en_US |
dc.subject | Hazards | en_US |
dc.subject | MDR-TB | en_US |
dc.subject | Risk factors | en_US |
dc.subject | Survival data | en_US |
dc.title | The importance of the frailty effect in survival models : for multidrug-resistant tuberculosis data | en_US |
dc.type | Article | en_US |
dc.date.updated | 2024-02-09T09:54:39Z | - |
dc.identifier.doi | 10.2174/18749445-v16-230912-2023-76 | - |
local.sdg | SDG03 | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairetype | Article | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
Appears in Collections: | Research Publications (Applied Sciences) |
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TOPHJ Copyright clearance.docx | Copyright clearance | 150.39 kB | Microsoft Word XML | View/Open |
Mbona_Mwambi_Ramroop_2023.pdf | 949.31 kB | Adobe PDF | View/Open |
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