Please use this identifier to cite or link to this item: https://hdl.handle.net/10321/4979
DC FieldValueLanguage
dc.contributor.advisorPrakaschandra, Rosaley-
dc.contributor.advisorWeich, Hellmuth-
dc.contributor.advisorDoubell, Anton-
dc.contributor.advisorSteyn, Jan-
dc.contributor.authorDlamini, Sanele Maxwellen_US
dc.date.accessioned2023-09-14T09:24:50Z-
dc.date.available2023-09-14T09:24:50Z-
dc.date.issued2023-
dc.identifier.urihttps://hdl.handle.net/10321/4979-
dc.descriptionSubmitted in partial fulfilment of the requirements for the Master of Health Sciences: Clinical Technology (Cardiology) at the Durban University of Technology, Durban, South Africa, 2023.en_US
dc.description.abstractBackground Cardiac resynchronization therapy (CRT) improves quality of life in heart failure patients who have a QRS duration ≥120 ms. Relatively few patients presenting with heart failure to the Division of Cardiology at Tygerberg Hospital are candidates for CRT, mainly because of a QRS duration <120 ms. Objectives The objectives of this study were to determine the QRS duration in a diverse cardiomyopathy population served by Tygerberg Hospital and to identify possible determinants of QRS duration in this cardiomyopathy population. Method Approval for this study was obtained from Stellenbosch University Health Research Ethical Committee and Tygerberg Hospital and all patients signed informed consent. Patients with a left ventricular systolic function (LVEF) <35% were recruited prospectively from the cardiac clinic. LVEF was determined by echocardiography using Simpson’s biplane method. QRS duration was measured on a standard 12 lead ECG. Results Two hundred patients were included. The mean age was 52 years (range 18-84). Self identified ethnicity revealed 63% coloured, 22% black and 15% white patients. The mean QRS width was 105 ms. On univariate analysis, parameters associated with a QRS width ≥120 ms included: ethnicity (White >Coloured >Black) (p = 0.01), ischaemic heart disease (<0.01), age (<0.01), left ventricular size (p = 0.03) and male gender (p = 0.05). After correcting for covariates in a multivariate analysis, ethnicity and sex were no longer predictive of a broad QRS. Conclusion Although it appeared on first evaluation that there was a gender and ethnic disparity in candidates for CRT, multivariate analysis revealed that this is more likely due to differences in age, ischaemic aetiology and LV size.en_US
dc.format.extent92 pen_US
dc.language.isoenen_US
dc.subjectCardiac resynchronization therapy (CRT)en_US
dc.subjectQRS durationen_US
dc.subject.lcshElectrocardiographyen_US
dc.subject.lcshMyocardium--Diseases--Patients--South Africa--Western Capeen_US
dc.subject.lcshCardiac pacemakersen_US
dc.subject.lcshHeart--Ventricles--Diseasesen_US
dc.subject.lcshHeart--Diseases--Treatmenten_US
dc.titleDeterminants of QRS duration in a diverse cardiomyopathy population of the Western Cape : implications for eligibility for cardiac resynchronization therapyen_US
dc.typeThesisen_US
dc.description.levelMen_US
dc.identifier.doihttps://doi.org/10.51415/10321/4979-
item.languageiso639-1en-
item.openairetypeThesis-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.grantfulltextopen-
Appears in Collections:Theses and dissertations (Health Sciences)
Files in This Item:
File Description SizeFormat
Dlamini_SM_2023.pdf2.04 MBAdobe PDFView/Open
Show simple item record

Page view(s)

184
checked on Dec 22, 2024

Download(s)

131
checked on Dec 22, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.