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Title: Urea/oxalamide tethered b-lactam-7-chloroquinoline conjugates: Synthesis and in vitro antimalarial evaluation
Authors: Singh, Pardeep 
Raj, Raghu 
Singh, Parvesh 
Gut, Jiri 
Rosenthal, Philip J. 
Kumar, Vipan 
Keywords: b-Lactam-7-chloroquinoline conjugates;Urea/oxalamide linker;Antimalarial evaluation;Structureeactivity relationship
Issue Date: 9-Nov-2013
Publisher: Elsevier
Source: Singh, P.; Raj, R.; Singh, P.; Gut, J.; Rosenthal, P. J. and Kumar, V. 2014. Urea/oxalamide tethered b-lactam-7-chloroquinoline conjugates: Synthesis and in vitro antimalarial evaluation. European Journal of Medicinal Chemistry. 71 (2014) 128-134.
Journal: European journal of medicinal chemistry 
The manuscript pertains to the synthesis of urea/oxalamide tethered b-lactam-7-chloroquinoline con-jugates with well modulated chain lengths and their antimalarial evaluation. The results reveal the dependence of activity profiles on the N-1 substituent of the b-lactam ring, the nature of the linker as well as the length of the alkyl chain. The most potent of the tested compounds showed an IC50 of 34.97 nM against chloroquine resistant W2 strain of Plasmodium falciparum.
ISSN: 0223-5234
Appears in Collections:Research Publications (Applied Sciences)

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