Please use this identifier to cite or link to this item:
Title: Evaluation of enantioresolution of (±)-catechin using electrokinetic chromatography and molecular docking
Authors: Sabela, Myalowenkosi Innocent 
Singh, Parvesh 
Gumede, Njabulo Joyfull 
Bisetty, Krishna 
Sagrado, Sagrado 
Keywords: Enantioresolution;Electrokinetic chromatography (EKC);Molecular docking
Issue Date: 2012
Publisher: SRP
Source: Sabela, M.I., Singh, P., Gumede, N.J., Bisetty, K. and Sagrado, S. 2012. Evaluation of Enantioresolution of (±)-Catechin using Electrokinetic Chromatography and Molecular Docking." Journal of Scientific Research in Pharmacy. 1(2): 1-4.
Journal: Journal of scientific research in pharmacy 
This study involves the enantioresolution of (±) catechin with the highly sulphated beta cyclodextrin (HS-β-CD) as a chiral selector using capillary electrophoresis (CE). The purpose of this study was to be tter understand enantioresolution amongst host-guest interactions. Furthermore, molecular docking was carried out to elucidate the mechanism of the enantioselective separations of (±) catechin enantiomers obtained in Electrokinetic chroma tography (EKC). A large difference in the interaction energies observed between the two enantiomers represents significant enantiodifferentiation. Our results also suggest that the host-guest interactions between the phenyl ring of the ligand and the open cavity of the HS-β-CD are due mainly to hydrophobic interactions. Interestingly, the stronger interactions observed with (+)-catechin is consistent with the elution order observed in the CE experiments.
ISSN: 2277-9469
Appears in Collections:Research Publications (Applied Sciences)

Files in This Item:
File Description SizeFormat
bisetty_et_al_non_acc_2012_output.pdf1.07 MBAdobe PDFThumbnail
Show full item record

Page view(s) 50

checked on Jul 20, 2024

Download(s) 50

checked on Jul 20, 2024

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.