Venugopala, Katharigatta NarayanaswamyPrasanna, Renuka T.Odhav, Bharti2015-07-272015-07-272013Venugopala, K. N.; Prasanna, R. T. and Odhav, B. 2013. Trifluoroacetic acid: An efficient catalyst for paal-knorr pyrrole synthesis and its deprotection. Asian Journal of Chemistry. 25(15): 8685-8689.0970-7077http://hdl.handle.net/10321/1306In the present work, we demonstrated a simple and an efficient method for the condensation of substituted aryl/heteroaryl amines with acetonylacetone in the presence of trifluoro acetic acid to afford the corresponding 2,5-dimethyl-1-substitued pyrroles using Paal-Knorr synthesis in excellent yields. Trifluoroacetic acid was used under reflux condition for the deprotection of 2,5-dimethyl-1-substitued pyrroles to their corresponding substituted aryl/heteroaryl amines in moderate yields. 2,5-Dimethyl-1-substitued pyrrole were characterized by NMR and LC-MS. The yield of the compounds was found to be excellent. - See more at: http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=25_16_103#sthash.ZgrkcJg7.dpuf5 penDeprotectionAmineTrifluoroacetic acidPaal-Knorr pyrrole synthesisProtectionAcetonylacetoneArticle10.14233/ajchem.2013.15185