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Title: Antimicrobial and antioxidant activities of substituted halogenated coumarins
Authors: Kasumbwe, K.
Venugopala, Katharigatta Narayanaswamy 
Mohanlall, Viresh
Odhav, Bharti 
Keywords: Coumarin;Antibacterial;Antioxidant;Antioxidant
Issue Date: Feb-2014
Publisher: Academic Journals
Source: Kasumbwe, K.; Venugopala, K.N.; Mohanlall, V. and Odhav, B. 2014. Antimicrobial and antioxidant activities of substituted halogenated coumarins. Journal of Medicinal Plant Research. 8(5) : 274-281
Journal: Journal of medicinal plant research ItemCrisRefDisplayStrategy.journals.deleted.icon
Abstract: Pathogens frequently display resistance to current drugs, which frequently lack selectivity/efficacy and
have detrimental side effects. Thus, there is a constant need for novel therapeutic agents. Coumarins
belong to the family of lactones, having a benzopyrone system that can be isolated from plants as well
as total synthesis that can be carried out in the laboratory. To date, many chemical reactions have been
established that can be used to synthesize coumarins. The synthesis of coumarins and their derivatives
has attracted the attention of organic and medicinal chemists, as these are widely used as fragrances,
pharmaceuticals and agrochemicals. In the present study, the antimicrobial and antioxidant activities of
substituted coumarin analogue compounds have been screened. 3-(2-bromoacetyl)-2H-chromen-2-one
(CMRN3) and 3-(2, 2-dibromoacetyl)-2H-chromen-2-one (CMRN6) showed bacterial growth inhibition for
all the tested species except Klebsiella pneumonia and Bacillus stearothermophilus. CMRN4 and
CMRN5 displayed moderate bacterial inhibition against Bacillus cereus, Micrococcus luteus,
Staphylococcus aureus. CMRN3 and CMRN6 had a minimum inhibition concentration at 0.75 mg/ml
against B. cereus, Bacillus coagulans, and Streptococcus faecalis. They displayed a minimum
inhibitory concentration (MIC) of 1.5 mg/ml against Escherichia coli and S. aureus. (CMRN5) displayed
an MIC at 0.75 mg/ml against M. luteus and 1.5 mg/ml against S. aureus. Compounds3-(2-bromoacetyl)-
6-chloro-2H-chromen-2-one (CMRN4), 3-(2-aminothiazol-4-yl)-6-bromo-2H-chromen-2-one(CMRN7), 3-
acetyl-6-bromo-2H-chromen-2-one (CMRN1) exhibited potent antioxidant activity at 85, 61 and 56%,
respectively, as evaluated by the DPPH free radical method.
ISSN: 1996-0875
Appears in Collections:Research Publications (Health Sciences)

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